Endocrine Abstracts

We report a 29-year old primiparous woman, presenting 3-days post vaginal delivery with a severe frontal headache of gradual onset but particularly severe whenever she tried breastfeeding and accompanied by vomiting. She was conscious, mildly dehydrated and apyrexial. Reflexes were globally brisk and besides for neck stiffness the rest of her central nervous system and major systemic examination was normal. FBC and clotting were normal, C-reactive protein 35 (normal <5). G...

We report a 26 year old Asian lady referred to our clinic with secondary infertility and a raised testosterone. She had miscarried at 6 weeks a year earlier. Over the last 6 months her periods had become irregular (every 6–8 weeks) had gained 9 kilograms in weight despite an unchanged diet. Along with this she had noticed an increase in facial and body hair. Testosterone checked by her GP was markedly elevated at 5.2 nmols/L (N<2.8).Prolactin 214 mu/L (0–650), ...

Between March 1998 and October 2002, 62 patients requiring trans-sphenoidal pituitary surgery (PS) and 36 patients requiring endoscopic sinus surgery (controls, C) were recruited. Patients were aged 18–65 years and had not had previous surgery or radiotherapy to the brain. The mean ages (p>0.05) and genders (p>0.05) of the two groups were similar 47 years, 41% male (PS) compared with 43 years, 39% male (C). Baseline IQ of the two groups was also similar, 101&#177...

A 5-month-old child presented with progressive lethargy and loss of motor skills. His mother had pre-existing type 1 diabetes with good glycaemic control throughout gestation (HBA1c 7.3% at booking, 5.5% at 20 weeks). She was euthyroid during pregnancy but had a high titre of thyroid microsomal antibodies (25600). Full blood count was normal at booking and delivery (haemoglobin 12.3 and 11.8 grams per decilitre, MCV 83 and 84 respectively). She was not vegetarian.The child...

Background: Maternal hyperthyroidism (MH) during late pregnancy is associated with adverse neonatal outcomes but the effects of MH in early gestation when managed in a specialised joint obstetric endocrine clinic setting is unclear. Objectives: To evaluate the obstetric and neonatal outcomes of maternal hyperthyroidism presenting during early gestation. Methods: Endocrine and obstetric record of 40 pregnancies with active hyperthyroidism managed in the antenatal endocrine clin...

Surgery and radiotherapy are used in the treatment of pituitary tumours. Treatment regimens for pituitary tumours vary depending upon perceived risks of radiotherapy.The aim of the study was to determine whether pituitary disease itself, surgery or radiotherapy, affect cognitive function. This was a controlled prospective design. Two groups were studied, transphenoidal adenomectomy (TSA) pituitary patients (active), and functional endoscopic sinus surger...